In Honor of Otto Jírovec
If I could talk to Otto (if you don´t know who Otto Jírovec is, but you know Taylor Swift ... stay calm and keep reading. Old school), I’d start by telling him that a lot of things have changed since his days of describing that “interesting rare pneumonia in children” back in the 1930s. I’d mention the internet, AI, the Human Genome Project… and of course, Instagram. But then I’d have questions — serious ones . How is it possible that 40+ years later, with all our technology, Pneumocystis jirovecii is still unculturable? Yes, Otto, we named a bug after you. And second surprise: it’s a fungus. And to be fair, it’s a weird fungus — no ergosterol, lots of glucans. Then I’d explain that today we have four treatment options: ( SPOILER ALERT: not antifungals ) TMP-SMX (oral or IV) — Gold standard Atovaquone - an inhibitor of mitochondrial Complex III Clindamycin + primaquine Pentamidine - a.k.a. Thanos [ No Otto, I wont even try to explain that ] Oh, I al...