Diabetes and cancer, a Bitter Connection

-

By 2045, an estimated 700 million people—10.9% of the global population—will be living with diabetes.

And Oncologists should care. Why? Because robust evidence links type 2 diabetes with higher risks of breast cancer, intrahepatic cholangiocarcinoma, colorectal cancer, and endometrial cancer. Before you roll your eyes, thinking this is just a random correlation from a forgotten journal… it’s not. This comes from an umbrella review—basically the academic way of saying, “we reviewed all the reviews, and it´s solid.”

Turns out, the long-suspected culprits behind neoplasia—chronic inflammation, hyperinsulinism acting as a growth promoter, and shared risk factors like obesity and inactivity—aren’t just theories anymore. They’re backed by data. And they play a role in the diabetic process.

So no, we can’t push for mammograms while ignoring weight gain, insulin resistance, and metabolic health. It’s all connected.

🍬Bhawalkar, J., Nagar, A., Rathod, H., & Verma, P. (2024). Navigating the Landscape of Cancer From Ancient Times to Modern Challenges: A Narrative Review. Cureus, 16(7), e65230. https://doi.org/10.7759/cureus.65230

☔Tsilidis K K, Kasimis J C, Lopez D S, Ntzani E E, Ioannidis J P A. Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies BMJ 2015; 350 :g7607 doi:10.1136/bmj.g7607


**** Now, I’m going to state the obvious: it’s amazing what AI like Sora can create with just a simple promt. Art.

Comments

Post a Comment

Popular posts from this blog

Medical knowledge

-
Image
  During medical school, I used to think that we were building a tall tower, starting with a solid foundation and then adding the next floors. After reading this article, I thought: what if it's more like a cake? I mean, each year we gain more knowledge (of course), but we also acquire experience in patient interactions, physical examinations, resilience, and communication skills. We also get better at understanding the healthcare system and how to search for information in databases. Then, the mission wouldn’t be just to become a great doctor; it would be to become a complete one. 😃 Ann Eye Sci. 2017 Jul; 2: 36.
Read more

Blue-Green warrior

-
Image
¿WHAT ARE YOU? Gram-negative, oxidase-positive, aerobic rod Motile, non-lactose fermenting Produces pyocyanin (blue pigment) and pyoverdin (green) Smells like grape Kool-Aid (yes, seriously) Pseudomonas  literally means “false unit”, a term microbiologists used to describe bacteria that resembled other motile rods but didn’t quite fit the mold.  They said: you look like a regular bacillus… but you’re not fooling us . Aeruginosa  means “full of copper rust”, a reference to the distinctive blue-green pigment it produces — specifically pyocyanin and pyoverdin. Pseudomonas aeruginosa is a pathogen which causes serious problem in cystic fibrosis lungs (Necrotizing pneumonia). It doesn’t just cause pneumonia. This pathogen can also cause Ecthyma gangrenosum (immunocompromised), Hot tub folliculitis (Rexaled), malignant otitis externa, burn wound infections, and even microbial keratitis (yes, those contact lenses aren’t as innocent as they look 🙄- Humor sense broken) He’s ever...
Read more